The mRNA targets of miRNA can be determined by using ... However, manipulating these different forms of RNA to effectively reduce gene expression is not always so easy. Investigators have ...

在全球范围内，结直肠癌（CRC）是导致癌症相关死亡的主要原因之一。近年来，随着 CRC 筛查项目的广泛开展以及内镜成像技术的进步，T1 期结直肠癌（一种侵犯黏膜下层的病变）的诊断数量显著增加。这一变化促使临床治疗 T1 期 CRC 的方式发生了转变。

complicating comparison of microRNA amounts in a sample. Figure 2: DGE profiling analysis of a synthetic RNA pool. To determine whether DGE profiling allows for differential expression analysis ...

One strand of the mature miRNA duplex, known as the guide strand, is incorporated into the RNA-induced silencing complex (RISC ... This complex regulatory network allows miRNAs to fine-tune gene ...

The tiny strings of RNA promote translation of a protein implicated in cancer ... (the process by which sugary molecules are stuck onto proteins), they weren’t expecting to find any ramping up gene ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi ... 1 Scientists have harnessed RNAi in the laboratory to ...

"These new insights could allow us to regulate gene expression more precisely for ... process and the production of a different type of RNA: microRNA. Zhang's lab has been investigating Serrate ...

You can gain deeper understanding of expression patterns of small non-coding RNAs by using assays that retain spatial organization at single cell resolution. Traditional methods such as NGS, can ...

When a gene is to be expressed, the base sequence of DNA is copied or transcribed into mRNA (messenger RNA). This process takes place in the nucleus and occurs in a series of stages. The two ...

“What excites us most about this discovery is that it indicates plants may control their microbiomes, in part, by regulating gene expression in microbes using cross-kingdom RNA ...

In a new study led by graduate student Ike Emerson in the Conlon lab, researchers discovered that a microRNA called miR-871 ... in biology can be established after a gene is turned on." MicroRNAs are ...