An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged ...

This work illuminates the essential role of epithelial ATG5 in defending against P. aeruginosa. Atg5 deficiency impairs bacterial clearance and aggravates inflammation via inflammasome activation, and ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

A new study unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing with CRISPR-Cas9, the team has been able to study these proteins without altering ...

Your body has a natural mechanism to do just that, a kind of internal superpower for recycling and renewal. It's called autophagy, and understanding it a bit can give an unexpected boost to your ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...