Adrenomedullin is increased in acute liver failure syndromes (ALF and ACLF), and AMBP1 is, on the contrary, reduced, mirroring the severity of the disease expressed by the SOFA score. ADM affects ...

Review of the emerging understanding of trained immunity in the skin and how infection-driven cellular processes induce long-lasting immune adaptation and modulate skin barrier integrity.

Monocytes, a special type of white blood cell, play an important role in the innate immune system and contribute to host defense in the blood by secreting large quantities of pro-inflammatory ...

Dr. Dobbs’ research interests include innate immunity to malaria and childhood infections of global health significance. She is currently principal investigator of a career development award studying ...

In a recent study posted in the Research Square* preprint server, which is under consideration at Scientific Reports, researchers examined the detailed mechanisms of ‘cytokine storm’ that induces ...

A study led by researchers at Queen Mary University of London has found that hormone replacement therapy (HRT) may help ...

Human umbilical vein endothelial cells (HUVECs) were seeded at 1 × 10 4 cells per cm 2 in six-well plates. Treatment with TNF-α (2.5, 5 or 10 ng/ml) or lipopolysaccharide (0.5, 1 or 5 μg/ml) treatment ...

Liver failure syndromes are characterized by a dysregulated immune response leading to immune paralysis. Adrenomedullin (ADM) is a potent vasodilator and immunoregulator. This study aimed to explore ...

In symptomatic cases, monocyte-related genes were strongly suppressed, and critical immune cells were depleted. Even in asymptomatic individuals, gene activity linked to monocyte function and ...