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A high-resolution 'map' reveals the structural and functional complexity of endogenous NMDA receptors in the brain
NMDA receptors, members of the excitatory ionotropic glutamate receptor family ... GluN1 and two alternative subunits, either GluN2 (N2A to N2D) or GluN3 (N3A and N3B). Over the past decade ...
Nature1y
Glutamate-induced neuron death requires mitochondrial calcium uptake
Glutamate acts at NMDA receptors in cultured rat forebrain neurons to increase the intracellular free calcium concentration. Although concurrent inhibition of mitochondrial calcium uptake ...
GEN1d
Fragile X Phenotypes Reversed in Mice by Targeting NMDA Receptors
MIT researchers suggests a potential molecular strategy for treating fragile X syndrome by enhancing NMDA subunit function.
Neuroscience News8d
How Ketamine Binds to Brain Receptors to Alter Mood
New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D.