Nucleoside analogs are transformative in cancer and antiviral therapies, offering new avenues for treatment despite ...

Nucleoside phosphorylases are enzymes that play a crucial role in the synthesis of nucleoside analogues, which are important compounds in the development of antiviral and anticancer drugs.

A number of nucleoside analogues which were expected to exhibit antibiotic activity were inactive because they are not substrates for the enzymes that phosphorylate nucleosides. Nucleotides themselves ...

In addition, some nucleoside analogue reverse transcriptase inhibitors (most notably zalcitabine and stavudine and, to a lesser extent, didanosine) represent an important contributor to peripheral ...

Lactic acidosis is a rare but often fatal complication reported in some human immunodeficiency virus (HIV)-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors.

Scientists at The University of Manchester and AstraZeneca have developed a new biocatalytic pathway that uses enzymes to produce nucleoside analogues, which are vital components in many ...