Bones are constantly being remodeled through the action of osteoclasts, which break down bone tissue, and osteoblasts, which create new bone tissue. Both cell types develop from immature precursor ...

The disease occurs when there's an imbalance between a person's osteoblasts – which are bone-building cells – and their osteoclasts, which are bone-degrading cells. Ordinarily, osteoclasts ...

Aldosterone also affects the function and creation of osteoblasts, which make bone, and osteoclasts, which dissolve and break them down. MR also is a receptor for aldosterone.

They observed that Fam102a promoted the differentiation of both osteoclasts and osteoblasts, and deletion of Fam102a resulted in an osteoporosis-like condition in mice, characterized by low bone ...