Bones are constantly being remodeled through the action of osteoclasts, which break down bone tissue, and osteoblasts, which create new bone tissue. Both cell types develop from immature precursor ...

The disease occurs when there's an imbalance between a person's osteoblasts – which are bone-building cells – and their osteoclasts, which are bone-degrading cells. Ordinarily, osteoclasts ...

They observed that Fam102a promoted the differentiation of both osteoclasts and osteoblasts, and deletion of Fam102a resulted in an osteoporosis-like condition in mice, characterized by low bone ...