p53 regulates the cell cycle via transcriptional activation of p21, 24,25 and Zac1 has been shown to be a co-activator of p53. 26 We investigated whether overexpression of mZac1 induced p21 ...

Cancer cell lines with wild-type p53 differ in their dependency on p21 for cell-cycle arrest. (a) p21 is upregulated by nutlin treatment of cancer cell lines.Exponentially growing RKO, HCT116 and ...

We attribute the p21-dependent heterogeneity in cell cycle activity to double-negative feedback regulation involving CDK2, p21, and E3 ubiquitin ligases. In support of this mechanism, analysis of ...

Background: P21 is a downstream effector protein of p53 that induces cell cycle arrest by inhibiting cyclin/cyclin dependent kinase (cdK) complexes. In this prospective correlative study, we ...

Activation of p53-p21 Pathway . DNA damaging agents activate the p53-p21 pathway causing cell cycle arrest and DNA repair 5.This mechanism is exploited by chemotherapeutic agents that induce p21 ...

A study addressing the complex regulation of HSCs, highlights p21's multifunctional nature beyond cell cycle control. Through the use of p21-tdTomato mice, researchers differentiate between p21 ...

Blocking the activity of a protein called p21 stops lung cancer cells entering a ‘sleep-like’ state that allows them to survive chemotherapy. Blocking p21 causes more cancer cells to die and ...