Cancer arises when your cells grow uncontrollably and refuse to die when they should. Normally, your body is equipped with ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

it took some time for scientists to realize that all four papers described the same protein. Once everybody got on the same page, the community settled on a common name: p53. “The field looked at this ...

Clinical research suggests that combining a novel agent called navtemadlin with DNA-damaging chemotherapy for the treatment of glioblastoma, a form of brain cancer, could increase efficacy.

However, the hope for improved outcomes might be in the reactivation of the p53 protein, a key player in cancer suppression. The p53 protein, is a tumor suppressor often inactivated in cancers by ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfil its task. Until now, researchers have assumed that the process is the same with all mutation types.

Likewise, our findings demonstrate that wood smoke could produce similar effects on p53, phospho-p53, and MDM2 protein expression as tobacco.