本综述系统阐述了PTEN（Phosphatase and TENsin homolog deleted on chromosome 10）在黑色素瘤中的多重抑癌机制。文章深入解析了PTEN通过 ...

前列腺癌中MYC过表达与PTEN双缺失协同促进细胞增殖和转移。转录组分析显示MYC单独激活细胞周期基因和翻译机制，而PTEN缺失加剧此效应。PTEN单缺失则抑制翻译基因，提示人类病变中PTEN缺失罕见的原因。 细胞周期调控基因和翻译机制相关基因表达的增加，可能 ...

To fulfil its lipid phosphatase function, PTEN must be in close proximity to the plasma membrane where its substrates reside. PTEN translocation to the plasma membrane is an active process that is ...

The share price of Patterson-UTI Energy, Inc. (NASDAQ:PTEN) surged by 14.62% between February 2 and February 9, 2026, putting ...

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children that shares many features of developing skeletal muscle. TBX2, a T-box family member, is highly upregulated in tumor cells ...

Investing.com - Piper Sandler将Patterson-UTI Energy (NASDAQ:PTEN)的目标价从7.00美元上调至9.00美元，同时维持对该股的"中性"评级。新目标价较当前8.54美元的价格代表约5%的上涨空间，尽管InvestingPro数据显示，基于公允价值计算，该股仍被低估。 该研究公司引用Patterson-UTI的"令人印象深刻的完工和自由现金流 ...

ctDNA Predicts Overall Survival in Patients With NSCLC Treated With PD-L1 Blockade or With Chemotherapy A next-generation sequencing–based cfDNA assay was used to profile 231 patients with mCRPC from ...

Rare disease charity PTEN Research Foundation welcomes two new senior leaders from the pharmaceutical industry, Professor Sir Mene Pangalos and Dr Donald Ogilvie to the Foundation’s Scientific ...

Genetic alterations targeting the PTEN tumor suppressor gene are among the most frequently noted somatic mutations in human cancers. Such lesions have been noted in cancers of the prostate and ...

Aging-US published "PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia via modulation of the nuclear factor-κB signaling pathway" which reported that this study was designed to ...