在这项研究中，研究人员通过饮食诱导的肥胖和前驱糖尿病小鼠模型，发现巨噬细胞在周围神经病变中起着神经保护作用。巨噬细胞在疾病早期就浸润到完整的周围神经中，其表达谱与神经退行性疾病相关的髓样细胞相似，并且通过 Gal - 3 延缓了终末轴突变性的发生。在 HFHFD 模型中，机械性异常疼痛在疾病早期出现，但 6 个月时会缓解；热痛觉减退在轴突终末变性可检测到之前就已出现，且与 Sarm1 基因相关。

Motor neurons in the different cranial motor nuclei extend axons, forming the cranial nerves, to innervate muscles and parasympathetic ganglia in the head and neck. The specification of the ...

A dramatic rise in type 2 diabetes has led to an increase in peripheral neuropathy. New research published in Nature from the lab of Clifford Woolf, led by Sara Hakim, at Boston Children's Hospital ...

Clinical signs of peripheral neuropathy were found in seven (21%) patients. Nerve conduction studies were abnormal in 24 (73%) patients. The pattern of involvement was predominantly of an axonal ...

An increase in high-fat, high-fructose foods in people's diets has contributed to a dramatic increase in type 2 diabetes.

Surrounding the individual axons is the collagenous tissue layer known as the endoneurium. This layer resists longitudinal stress and contributes to the formation of the endoneurial tube.

And IFNγ activates STAT1-cGAS signaling and cGAMP production in surrounding Schwann cells and blood cells, to promote peripheral axon regeneration.

The researchers suspected that peripheral neuropathy is caused by the immune system, so used single-cell sequencing to detect changes in immune cells near sensory neuron axons in peripheral nerves.

The neurologist explains the link between Guillain-Barre Syndrome and paralysis, and the initial symptoms to watch out for.