Single nucleotide polymorphisms (SNPs) are variations in a genome’s base pair in a DNA sequence, and occur in approximately 1 out of 800 base pairs. These occur when a single nucleotide is ...

The situation is further complicated by polymorphisms in the PAI-1 gene, particularly the 4G/5G polymorphism in its promoter region, which has been linked to various cardiovascular conditions.

Background Athlete's heart as an adaptation to long-time and intensive endurance training can vary considerably between individuals. Genetic polymorphisms in the cardiological relevant insulin-like ...

1. We studied a perch Perca fluviatilis L. population that during a 9-year period switched between a phase of dominance of adult perch and a phase dominated by juvenile perch driven by cannibalism and ...

Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conf ...

INDERJEET KAUR, SANGITA ROY, SUBHABRATA CHAKRABARTI, VIRINDER KAUR SARHADI, PARTHA P. MAJUMDER, A.J.S BHANWER, JAI RUP SINGH, Genomic Diversities and Affinities among Four Endogamous Groups of Punjab ...

To discover polymorphisms, we sequenced all exons and their boundaries, including 1.5 kb upstream of the LEPR gene, with 24 unrelated Korean DNA samples. We identified 35 sequence variants ...

Background: The carboxylesterase 2 (CES2) is a key enzyme for irinotecan bioactivation. The aims of this work were i) to search for genetic polymorphisms in promoter, coding sequence and intron-exon ...

Purpose. The effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors were examined. Pharmacogenetics examines the relationship between single-gene polymorphisms and the ...

Polymorphisms in Inflammation Genes and Bladder Cancer: From Initiation to Recurrence, Progression, and Survival . JCO 23 , 5746-5756 (2005). DOI: 10.1200/JCO.2005.01.598 ...