Dendritic cells (DCs) are critical in the maintenance of self-tolerance and altered functions of DCs have been implicated in the pathogenesis of a number of autoimmune diseases, ...

1. Identify the key roles of dendritic cells in cancer immunotherapy, including their use as antigen-loaded vaccines and intratumoral adjuvants. 2. Explain the strategies used to overcome tumor ...

Typically, dendritic cells present tiny fragments of biological material (known as antigens) for notice by other immune cells called T cells. This programs the T cell to launch an immune attack ...

However, cell therapy applications prefer serum-free media because they provide greater consistency and are often required to meet regulatory standards. In this application note, explore how ...

Without Siglec-E, dendritic cells stayed hyperactivated, producing more pro-inflammatory cytokines like TNF-α and IL-6, and driving stronger T-cell responses against the allograft.

Narasimhan, H., et al. (2025). RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells. Proceedings of the National Academy of Sciences.

Dendritic cells take up proteins from foreign pathogens, chop them up into peptides called antigens, and display them on their surface. CD4+ conventional T (Tconv) cells, or helper T cells ...

As the researchers demonstrate, dendritic cells that are marked by expression of the transcription factor RORγt - so-called RORγt+ dendritic cells (DCs) - are found in many tissues.

Northwest Biotherapeutics Announces Upcoming Presentation On Next Generation Dendritic Cells for Enhanced Anti-Tumor Treatments. PR Newswire. BETHESDA, Md., June 11, 2025.

Diakonos Oncology Closes $20 Million Financing to Accelerate Phase 2 Glioblastoma Clinical Development Program and Expand Use of Innovative Dendritic Cell Platform ...