Dendritic cells were pulse-chased at the indicated times with coupled latex beads. Cells were disrupted in lysis buffer and centrifuged at 150g for 4 min at 4 °C.

We have investigated whether dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can trigger B cells to produce antigen-specific antibodies without CD4+ T-cell help.

Typically, dendritic cells present tiny fragments of biological material (known as antigens) for notice by other immune cells called T cells. This programs the T cell to launch an immune attack ...

The activated T cells can then proliferate and differentiate. They can become either cytotoxic T cells that release potent cytotoxic chemicals such as perforins and granzyme to kill the invading agent ...

With her team, ETH Professor Halin has now discovered that dendritic cells can take a shortcut. In studies performed on mouse tissues and employing microscopy, the scientists were able to show that ...

Shortcut for dendritic cells Date: May 17, 2021 Source: ETH Zurich Summary: During an inflammatory response, things need to happen quickly: researchers have recently discovered that certain immune ...

A phase I trial of tumor-associated antigen-pulsed dendritic cell immunotherapy for patients with brain stem glioma and glioblastoma. Authors: S ... known to be expressed on gliomas and pulse ...

CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer. Cell Reports Medicine , 2024; 101479 DOI: 10.1016/j.xcrm.2024.101479 Cite This ...

Dendritic Cell Vaccine Before Surgery Promising in HER2+ Breast Cancer — Vaccine led to significant drop in peripherally circulating anti-HER2 T-cell response at week 6.

Patients will be treated with 6 weekly injections of dendritic cell (DC1) vaccines in combination with trastuzumab and pepinemab. We hypothesize these therapies may elicit CD4+ HER2-specific T cell ...