In bone-marrow-derived dendritic cells, ... Pulse-chase experiments and immunoprecipitations were performed as described 19. Briefly, splenocytes were pulsed for 45 min with 0.5 mCi ml-1 ...

We have investigated whether dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can trigger B cells to produce antigen-specific antibodies without CD4+ T-cell help.

Typically, dendritic cells present tiny fragments of biological material (known as antigens) for notice by other immune cells called T cells. This programs the T cell to launch an immune attack ...

Shortcut for dendritic cells Date: May 17, 2021 Source: ETH Zurich Summary: During an inflammatory response, things need to happen quickly: researchers have recently discovered that certain immune ...

With her team, ETH Professor Halin has now discovered that dendritic cells can take a shortcut. In studies performed on mouse tissues and employing microscopy, the scientists were able to show that ...

A phase I trial of tumor-associated antigen-pulsed dendritic cell immunotherapy for patients with brain stem glioma and glioblastoma. Authors: S ... known to be expressed on gliomas and pulse ...

How exactly dendritic cells get from the tissue into lymphatic vessels and from there to the lymph node is the focus of research conducted by Cornelia Halin, Professor of Pharmaceutical Immunology ...

The activated T cells can then proliferate and differentiate. They can become either cytotoxic T cells that release potent cytotoxic chemicals such as perforins and granzyme to kill the invading agent ...

Patients will be treated with 6 weekly injections of dendritic cell (DC1) vaccines in combination with trastuzumab and pepinemab. We hypothesize these therapies may elicit CD4+ HER2-specific T cell ...

CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer. Cell Reports Medicine , 2024; 101479 DOI: 10.1016/j.xcrm.2024.101479 Cite This ...

Dendritic cells (DCs) are critical in the maintenance of self-tolerance and altered functions of DCs have been implicated in the pathogenesis of a number of autoimmune diseases, ...