Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor ...

A sum of 921 samples were collected from three independent data sets. We obtained pyroptosis-related genes from both the Molecular Signatures Database and relevant literature sources and used four ...

近日，西安交通大学第一附属医院袁祖贻教授、吴岳教授、李铤教授团队在心血管代谢研究领域取得重要进展，其最新研究成果以“Gut Microbiota-Derived Isovaleric Acid Alleviates Atrial Fibrillation by Suppressing GSDME-Dependent Pyroptosis”为题（中文译：菌群来源的异戊酸通过GSDME焦亡通路抑制心房 ...

Body mass index (BMI) as a prelude to hepatocellular carcinoma (HCC) and metabolic dysfunction–associated steatohepatitis (MASH) risk factors in patients with no identified risk factor for developing ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

About 50% of the adult population throughout the world over the age of 70 years has chronic kidney disease (CKD) and renal fibrosis. Both CKD and renal fibrosis begin as pyroptosis, during which a ...

Promoting pyroptosis—an inflammatory form of programmed cell death—has become a promising treatment strategy for cancer. In research published in The FASEB Journal, investigators purified a long-chain ...

Chengdu Baiyu Pharmaceutical Co. Ltd. has synthesized NLRP3 inflammasome inhibitors acting as pyroptosis inhibitors reported to be useful for the treatment of cancer, autoimmune, cardiovascular, ...

This schematic shows the cell death pathway called pyroptosis, Greek for going down in flames. When activated by a toxin or an infection, the enzyme caspase-1 initiates several reactions inside of the ...