JPX通过形成BRD4-p65复合体促进内皮细胞衰老相关分泌表型（SASP），并证实Senolytics（达沙替尼+槲皮素）可有效抑制该复合体，为血管老化相关疾病的治疗提供新靶点。 血管内皮细胞衰老与JPX调控机制研究进展 （摘要部分） 该研究首次系统揭示了长链非编码RNA JPX ...

Cellular senescence refers to a state of irreversible arrest of cell proliferation. It was first described by Hayflick and colleagues in the 1960s when they observed cessation of cell proliferation ...

明尼苏达州罗切斯特 -- 衰老（senescent）或功能失调细胞的存在会使幼鼠加速衰老，另一方面， 在老年小鼠中使用Senolytics药物来去除这些坏细胞可以改善健康并延长寿命。 Mayo Clinic的研究人员和合作者的这些发现为这一衰老研究领域的发展奠定了基础。 该研究 ...

本研究针对糖尿病肾病(DKD)中细胞衰老和慢性炎症的关键病理环节，首次在动物模型和体外实验中系统验证了senolytic组合药物dasatinib+quercetin(D+Q)的肾脏保护作用。研究发现，短期"hit-and-run"给药方案可显著降低p16Ink4a阳性衰老细胞负荷，抑制NF-κB炎症通路，同时 ...

Senolytics—a class of drugs that reduce chronic inflammation and tissue damage in aging cells—are shown to eliminate 30% to 70% of "zombie" cells in the body. These zombie cells, known as senescent ...

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), ...

“This work provides new opportunities for the development of the next generation of ChE inhibitors that specifically target AChE and BChE associated with AD pathology.” “This work provides new ...

In a recent study published in the journal Nature Aging, an international team of researchers observed that senolytics can alleviate physiologic brain aging and coronavirus disease 2019 (COVID-19) ...

Senescent cells are a hallmark of aging. They have also been implicated in a broad spectrum of age-related diseases and conditions including cancer, diabetes, cardiovascular disease, and Alzheimer’s ...

Despite all the research happening around understanding Alzheimer’s disease in the past few decades, the reality is that scientists still don’t have great answers for struggling patients. This has led ...

Longevity research always reminds me of the parable of blind men and an elephant. A group of blind men, who’ve never seen an elephant before, each touches a different part of the elephant’s body to ...