2024年3月13日，中国科学院动物研究所曲静研究组、刘光慧研究组联合中国科学院北京基因组研究所张维绮课题组在Developmental Cell在线发表了题为“The sirtuin-associated human senescence program converges on... Sirtuin蛋白是一类从古细菌到人类高度保守的去乙酰化酶，其酶活 ...

1979年，加州大学伯克利分校的一位科学家在对酵母的研究中发现了一种可以使基因座沉默的蛋白（MAR1），同年晚些时候又有三种具有类似功能的蛋白质被发现，经过统一命名，它们成为了Sir蛋白家族（沉默信息调节蛋白），而MAR1也被更名为Sir2。随着在其它各 ...

sirtuin酶在年龄相关疾病（包括心血管疾病）中的潜在保护作用仍然是一个深入研究的领域。现在，研究人员已经确定，老化心脏中的sirtuin 1（SIRT1）和sirtuin 3（SIRT3）水平下降，破坏心肌细胞（心肌细胞）在缺血再灌注损伤时收缩的能力。 现在,一项新的临床前 ...

Jellyfish, sea sponges, amoebas and other animals on the early branches of the tree of life defy conventional aging. A new study reveals diversity of proteins called sirtuins in these animals compared ...

Animals on the early branches of the tree of life, such as jellyfish and sea sponges, defy the usual conventions of aging. Some show abilities to regenerate damaged or missing tissues, halt or reverse ...

Study reveals that Sirtuin 7 regulates the functions of brown adipose tissue, thereby playing a critical role in overall energy regulation. Mammals convert the energy stored in adipose (fat) tissue ...

Sirtuin genes and the proteins they encode were already linked to longevity in yeast. Now, a previously overlooked member of the family has excited researchers who study aging At last, a member of the ...

A potentially promising approach to treating Alzheimer’s disease has been developed by researchers studying sirtuin, a protein thought capable of extending lifespan in laboratory animals. Using mice ...