Scientists from Johns Hopkins and the University of Wisconsin have discovered that a protein called Sir2, which is found in nearly all living cells, has a new function that might help explain how ...

Scientists from Johns Hopkins and the University of Wisconsin have discovered that a protein called Sir2, which is found in nearly all living cells, has a new function that might help explain how ...

研究鉴定了脊椎动物特有的非经典sirtuin蛋白FAM118B和FAM118A，发现它们与细菌抗噬菌酶高度相似，具有头尾相连的成纤维特性及协同NAD处理功能。结构分析表明其缺乏锌结合模块，但保留了NAD结合和催化关键位点。细胞实验证实二者在高表达时可形成动态焦点，且 ...

Breast cancer is the most common cancer to affect women, with over 40 000 new cases being detected and around 13 000 women dying from the disease in Britain each year (CancerStats, 2005). The ...

New insights into a family of metabolites, acylspermidines, could change how we understand aging and fight disease. A new study presents an unexpected connection between spermidine, a long-known ...

Naturally occurring pigments in berries, also known as anthocyanins, increase the function of the sirtuin 6 enzyme in cancer cells, a new study from the University of Eastern Finland shows. The ...

The enzyme sirtuin 6, or SIRT6, serves many key biological functions in regulating genome stability, DNA repair, metabolism and longevity, but how its multiple enzyme activities relate to its various ...

The human heart is a remarkable muscle, beating more than 2 billion times over the average life span. But the heart's efficiency can decrease over time. One major contributor to this decreased ...