Emerging findings in T cells indicate that nuclear receptors use a combination of activation and repression pathways to regulate the differentiation and function of distinct helper T cell subsets.

CD19-directed chimeric antigen receptor (CAR) T cells are clinically effective in a limited set of leukemia patients. However, CAR T-cell therapy thus far has been largely restricted to targeting ...

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve cell therapies.

Although scientists can learn a lot from cell culture and animal models, they cannot truly substitute for all parts of the human body, especially the brain. But scientists have now used human brain ...

Araç's lab has been working for 11 years to reveal the structure of full-length aGPCRs, hoping to learn how incoming signals are transmitted from outside to inside the cell. These receptors are ...