CD19-directed chimeric antigen receptor (CAR) T cells are clinically effective in a limited set of leukemia patients. However, CAR T-cell therapy thus far has been largely restricted to targeting ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with variations in receptor function. Computational protein structure prediction ...

Emerging findings in T cells indicate that nuclear receptors use a combination of activation and repression pathways to regulate the differentiation and function of distinct helper T cell subsets.

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve cell therapies.

Although scientists can learn a lot from cell culture and animal models, they cannot truly substitute for all parts of the human body, especially the brain. But scientists have now used human brain ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...