本研究针对阿尔茨海默病(ad)中神经炎症标志物tspo(转运蛋白18kda)上调的机制不明问题，通过5xfad转基因小鼠模型和psen1-e280a突变ad患者脑组织研究，首次揭示tspo上调由接触aβ斑块的小胶质细胞驱动，且该现象最早出现在海马下托区。研究证实tspo是ad早期神经炎症的生物标志物，为tspo-pet成像和靶向治疗 ...

为探究肺部炎症中转运蛋白 18kda（tspo）的表达水平，研究人员开展了合成新型光学探针的研究。合成的 fitc-mbp 能特异性识别 tspo，在肺部炎症模型小鼠体内可聚集于肺部，或可用于可视化过表达的 tspo。

线粒体转位蛋白（tspo）是一种可以被正电子断层扫描观察到的炎症标志物，它在ad患者小胶质细胞中显著上调[2]，有研究表明靶向tspo可以减轻ad[3,4 ...

为了确定tspo对神经炎症的影响，研究团队对lps刺激前后的海马区进行了rna测序。结果显示，在未刺激时，野生型（wt）以及tspo敲除（tspo-ko）小鼠 ...

The expression of TSPO, a mitochondrial translocator protein involved in steroid synthesis, in the nervous system is altered in numerous neurological and psychiatric conditions. Rupprecht and ...

When compared to the TSPO-specific tracer ¹⁸F-D2-LW223, ¹⁸F-PDE-1905 demonstrated superior image quality and greater brain distribution, underscoring its promise for imaging neuroinflammation.

TSPO within Microglia Surrounding Beta-Amyloid Plaques in an Alzheimer's Disease Brain. Credit. FIU Robert Stempel College of Public Health & Social Work. Usage Restrictions. NA. License.

27 May 2022. Researchers rely on TSPO PET imaging to evaluate neuroinflammation in living people. But what does this signal actually measure? In a May 11 preprint on bioRxiv, researchers led by David ...

"TSPO could be of relevance both for clinical studies on NPC as for clinical routine. PET imaging might be difficult with young patients, as they need to stay calm while in the scanner.