Scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood -- known as the tertiary lymphoid structure -- where they become ...

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of ...

Scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood – ...

TLSs are highly organized structures that typically appear as clusters of B-cells containing FDCs. These clusters are then surrounded by T-cells and HEVs as shown schematically in Figure 1.

The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer ...

Tertiary lymphoid structures, which contain Helper T cells, B cells and natural killer cells, create a favorable environment for immune cell maturation and indicate cancer treatments are more ...

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign ...

Exceptional responses in RCC are associated with higher clonal neoantigen load and enriched B-cell receptor signaling pathways. Tertiary lymphoid structure signatures and increased metabolic activity ...