The syndrome X-SCID is caused by faulty expression of the γ-chain of the interleukin-2 receptor (IL2RG), which results in diminished lymphoid-cell survival and proliferation. Gene therapy can ...

In human gene therapy for X-SCID, an analogous growth advantage would greatly enhance the repopulation of lymphocytes derived from a very small number of γc gene-supplemented precursors.

NEW ORLEANS -- Genetic therapy appeared to restore the immune system of patients with X-linked severe combined immunodeficiency (SCID), but without leading to leukemia as a side effect, researchers re ...

X-linked severe combined immunodeficiency disease (X-SCID) is a rare genetic disorder characterized by profound defects in T-cell, B-cell, and natural killer (NK) cell function, caused by ...

Mouse Study Reveals Human X-SCID Gene Therapy Poses Substantial Cancer Risk. ScienceDaily . Retrieved June 4, 2025 from www.sciencedaily.com / releases / 2006 / 04 / 060430002334.htm ...

The second edition of the only comprehensive textbook on inherited disorders of the immune system, co-edited by UCSF Professor of Pediatrics and Human Genetics Jennifer Puck, MD, will soon be ...

Long-term follow-up of 16 boys treated with gene therapy to correct the immune deficiencies ADA-SCID and X-SCID in a British study has shown that despite some heartbreaking setbacks along the way, ...

A new gene therapy technique could treat X-SCID or "bubble boy" disease, a serious and rare immune disorder, according to the NIH.

In four studies being presented today during the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta, researchers announce promising findings on innovative tools and ...

The new approach appears safer and more effective than previously tested gene-therapy strategies for X-SCID. Infants with X-SCID, caused by mutations in the IL2RG gene, are highly susceptible to ...

(Medical Xpress) -- Researchers at the UCL Institute of Child Health have developed gene-therapy programmes that can successfully treat children born with an inability to fight infections ...