eIF4E 家族在真核生物的翻译起始过程中具有重要地位，其蛋白质多样性体现在不同生物体的异构体差异、结构特点以及功能的多样性上。eIF4E 在肿瘤发生、应激反应和病毒感染等过程中都发挥着关键作用，同时，其功能受到多种精细调控机制的调节。

研究发现，eIF4E与帽端的结合可以通过eIF4G进一步稳定，同时引导eIF4A在正确的区域展开解旋活动。 而这种协作不仅提高了翻译效率，也赋予了翻译 ...

The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor in protein translation. Sonenberg and colleagues show that phosphorylation of eIF4E modulates the antiviral response by ...

These phosphorylation events control the Maskin-eIF4E interaction and, as a result, translation of cyclin B1 mRNA. Cell cycle progression requires this Maskin-mediated translational regulation.

RESULTS: All 65 patients had elevated levels of eIF4E in the tumors. Thirty-six patients (55%) had elevated eIF4E in histologically tumor-free margins, and 20 of these patients (56%) have had ...

The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well as others.

About eIF4E. Eukaryotic translation initiation factor 4E (eIF4E), the main regulatory component of cap-dependent mRNA translation, selectively promotes pro-oncogenic protein synthesis in response ...

Ribometrix Inc. recently discussed the discovery and preclinical evaluation of a novel potent and selective eukaryotic translation initiation factor 4E (eiF4E) inhibitor, RBX-6610, being developed for ...

Several investigations on crop and model plants have confirmed that VPg-eIF4E/(iso)4E interaction is necessary for potyvirus infection. We investigated the functions of the VPg-eIF(iso)4E interaction ...

DURHAM, N.C.--(BUSINESS WIRE)--Ribometrix, a biotechnology company developing small molecule therapeutics that modulate RNA biology, presented the latest data from its eIF4E program at the ...