The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we report the cDNA ...

本研究针对骨髓(BM)与外周血(PB)微循环对骨组织止血平衡的调控机制展开探索。研究人员通过对比BM与PB对成骨细胞和内皮细胞(HUVECs)的作用，发现BM血浆显著降低肝素酶(heparanase)、组织因子(TF)等促凝因子表达，同时增强内皮细胞增殖和血管形成能力。研究首次揭示BM微循环通过抑制肝素酶-TF复合物 ...

2021年3月19日 讯 /生物谷BIOON/ --近日，一项刊登在国际杂志JCI Insight上的研究报告中，来自芝加哥大学伊利诺伊大学等机构的科学家们通过研究发现 ...

Background: Our laboratory previously demonstrated that heparanase (HPSE), an enzyme that cleaves heparan sulfate, upregulates growth factors and their receptors, resulting in enhanced multiple ...

In addition, inhibition of heparanase through the new inhibitors can impede the migration and proliferation of immortalized cells (that is, cells with uncontrolled cell growth).

Heparanase levels were significantly elevated in tongue cancer patients, suggesting that it might be useful as a diagnostic tool to monitor progression of this disease and response to treatment.

A research team from China developed short hairpin RNA against heparanase (HPA), and determined its effects on HPA expression and the malignant characteristics of gastric cancer cells. Their study ...

This is why researchers hypothesized that heparanase contributes to the pathogenesis of COVID-19 and that heparan sulfate may be inhibited with the use of low molecular weight heparins.

The UIC team examined how the heparanase protein, which is present in all our cells, affects reinfection from the herpes simplex virus type 1 in mice. They found that inhibiting heparanase ...

Synthetic heparanase inhibitors inhibit the spread of herpes viruses in tissue Date: September 7, 2023 Source: Wiley Summary: Herpes is not only unpleasant but it can, in some cases, also have ...