The UIC team examined how the heparanase protein, which is present in all our cells, affects reinfection from the herpes simplex virus type 1 in mice. They found that inhibiting heparanase ...

Once attached, the heparanase enzyme is unable to bind or cut heparin sulfate sugar chains around cells. In this way, the tissue around cells remains firm and inaccessible to dislodged cells.

Background: Our laboratory previously demonstrated that heparanase (HPSE), an enzyme that cleaves heparan sulfate, upregulates growth factors and their receptors, resulting in enhanced multiple ...

本研究针对骨髓(BM)与外周血(PB)微循环对骨组织止血平衡的调控机制展开探索。研究人员通过对比BM与PB对成骨细胞和内皮细胞(HUVECs)的作用，发现BM血浆显著降低肝素酶(heparanase)、组织因子(TF)等促凝因子表达，同时增强内皮细胞增殖和血管形成能力。研究首次揭示BM微循环通过抑制肝素酶-TF复合物 ...

K. Kumar /Götte investigated the functional interplay of the HS degrading enzyme heparanase, and its substrate Syndecan-1 in colon cancer using in vitro siRNA and mutant/wild-type plasmid ...

This is why researchers hypothesized that heparanase contributes to the pathogenesis of COVID-19 and that heparan sulfate may be inhibited with the use of low molecular weight heparins.

A phase I/IIA safety study of NPC-1C: A novel, therapeutic antibody to treat pancreas and colorectal cancers. Background: Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to conventional ...

Notably, heparanase is delivered to the neoplastic lesions in large part by infiltrating Gr1+/Mac1+ innate immune cells. A sulfated oligosaccharide mimetic of heparan sulfate, ...

The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we report the cDNA ...

A research team from China developed short hairpin RNA against heparanase (HPA), and determined its effects on HPA expression and the malignant characteristics of gastric cancer cells. Their study ...

Heparanase levels were significantly elevated in tongue cancer patients, suggesting that it might be useful as a diagnostic tool to monitor progression of this disease and response to treatment.