An increased concentration of the hormone leptin in fat cells is believed to be responsible for weight gain associated with antipsychotic drugs, according to research led by UT Southwestern Medical ...

Overall, hyperleptinemia has been linked to the presence of insulin resistance, T2DM and diabetic vascular complications. There are antidiabetic drugs that can lower leptin levels, ...

These data indicate that insulin resistance directly induces hyperleptinemia and cardiac contractile dysfunction, without affecting leptin-mediated cardiac contractile function at the myocyte level.