SHANGANG ZHAO,QIAN LIN,WEI XIONG, et al. Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders, Science Translational Medicine (2023).

Overall, hyperleptinemia has been linked to the presence of insulin resistance, T2DM and diabetic vascular complications. There are antidiabetic drugs that can lower leptin levels, ...

SP1 mice also displayed hyperinsulinemia, hyperleptinemia and impaired glucose tolerance. Pair-feeding SP1 mice to amounts consumed by non-transgenic mice prevented the increased body weight, ...

An increased concentration of the hormone leptin in fat cells is believed to be responsible for weight gain associated with antipsychotic drugs, according to research led by UT Southwestern Medical ...