We investigated the role of hypothalamic insulin signaling in the regulation of energy balance and insulin action in rats through selective decreases in insulin receptor expression in discrete ...

The MC4R agonist targets rare genetic and hypothalamic obesity, with potential as a combination or maintenance therapy for general obesity alongside GLP-1 agents.

Hypothalamic leptin signalling has a key role in food intake and energy-balance control and is often impaired in obese individuals. Here we identify histone deacetylase 5 (HDAC5) as a regulator of ...

Superluminal Medicines, a drug discovery company integrating AI/ML, protein dynamics, and structural biology to rapidly unlock the most challenging G protein-coupled receptors (GPCRs), today announced ...

Superluminal Medicines Inc. has commenced IND-enabling studies for its lead program, an orally administered, highly selective, biased melanocortin MC4 receptor (MC4R) agonist initially targeting rare ...

Setmelanotide was associated with significant weight reduction among patients aged 4 years and older with acquired hypothalamic obesity.

Please use one of the following formats to cite this article in your essay, paper or report: APA. Sidharthan, Chinta. (2023, March 14). Hypothalamic inflammation and obesity, study suggests a ...

Rhythm Pharmaceuticals jumps 36.6% after its oral drug bivamelagon shows strong BMI and hunger reductions in a phase II study in acquired hypothalamic obesity.

LAS VEGAS -- Obese patients who continue to have 'thyroid symptoms' even when their levels are normalized may have a hypothalamic dysfunction, researchers reported here.