Macrocyclic compounds can block nearly 80% of cancer's signature characteristic events to control cancer occurrence and progression, suggesting a space for using macrocyclic compounds in cancer ...

2023年2月2日，该研究工作以Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P？Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance为题发表于Journal of Medicinal ...

Macrocyclic peptides are small chains of amino acids that form loops. The shape is important: it provides more surface area for the peptides to disrupt protein-protein interactions, and it helps ...

Reactions: How macrocyclic peptides compare with natural products, how C&EN can cover climate change stewardship, and how business is implicated in chemistry’s poor image.

Hepatocyte growth factor (HGF) is involved in cancer progression through MET receptor signaling. Here, HiP-8, a 12 amino-acid macrocyclic peptide, was identified to selectively recognize active HGF.

Macrocyclic compounds can block nearly 80% of cancer's signature characteristic events to control cancer occurrence and progression, suggesting a space for using macrocyclic compounds in cancer ...

Bayer seeks European marketing authorization for investigational contrast agent, gadoquatrane: Berlin Friday, July 11, 2025, 11:00 Hrs [IST] Bayer announced the submission of a ma ...

Macrocyclic compounds are ring-shaped molecules made by connecting two ends of linear molecules. One of their unique and exciting properties is that their cyclical configuration reduces their ...

Idorsia Pharmaceuticals Ltd. has patented macrocyclic compounds acting as orexin OX2 receptor agonists reported to be useful for the treatment of obesity, pain, fatigue, inflammation, cognitive, sleep ...

Tsantrizos, Y. S. et al. Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection. Angew. Chem. Int. Ed. Engl. 42, 1356–1360 (2003) ...