This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger ...

Long noncoding RNAs (lncRNAs) could be a byproduct of transcription (i), a scaffold linking proteins (ii) or a guide bringing proteins to specified parts of the genome (iii).

Association studies provide genome-wide information about the genetic basis of complex disease, but medical research has focused primarily on protein-coding variants, owing to the difficulty of ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

The most commonly recognized function of RNA is to code for proteins in the body, but 75% of the human genome generates noncoding RNA that does not code for proteins. A substantial portion of these ...

Myocardial hypertrophy is a condition characterized by thickening of the ventricular wall and commonly associated with progression to heart failure. It develops when the heart is subjected to ...

To identify noncoding mutations that are associated with functional effects in cancer, Dr. Ideker’s team turned back to TCGA data and carried out a systematic analysis of 930 tumors, integrating ...

Noncoding mutations contribute to autism risk Date: December 13, 2018 Source: Simons Foundation Summary: A whole-genome sequencing study of nearly 2,000 families has implicated mutations in ...

Noncoding RNAs as master regulators in brain. According to Debra Silver, a developmental neurobiologist at the Duke University School of Medicine in North Carolina, researchers have for nearly half a ...

PURPOSELong noncoding RNAs (lncRNAs) were recently implicated in modifying pyroptosis. Nonetheless, pyroptosis-related lncRNAs and their possible clinical relevance persist largely uninvestigated in ...

Definitions Box: Long noncoding RNAs (lncRNAs) are RNAs longer than 200 nucleotides that do not contain any open reading frames greater than 300 nucleotides (100 codons). The DNA sequences they’re ...