We have investigated the association of the recently identified IL6R polymorphisms with the serum levels of soluble IL-6 receptor (sIL-6R). sIL-6R is generated by shedding of the membrane-bound ...

Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conf ...

Purpose. The effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors were examined. Pharmacogenetics examines the relationship between single-gene polymorphisms and the ...

Background Athlete's heart as an adaptation to long-time and intensive endurance training can vary considerably between individuals. Genetic polymorphisms in the cardiological relevant insulin-like ...

The anti–HER-2/neu monoclonal antibody trastuzumab has been shown to engage both activatory (fragment C receptor [FcγR]IIIa; FcγRIIa) and inhibitory (FcγRIIb) antibody receptors and FcγR polymorphisms ...

The situation is further complicated by polymorphisms in the PAI-1 gene, particularly the 4G/5G polymorphism in its promoter region, which has been linked to various cardiovascular conditions.

Polymorphisms in Inflammation Genes and Bladder Cancer: From Initiation to Recurrence, Progression, and Survival . JCO 23 , 5746-5756 (2005). DOI: 10.1200/JCO.2005.01.598 ...

INDERJEET KAUR, SANGITA ROY, SUBHABRATA CHAKRABARTI, VIRINDER KAUR SARHADI, PARTHA P. MAJUMDER, A.J.S BHANWER, JAI RUP SINGH, Genomic Diversities and Affinities among Four Endogamous Groups of Punjab ...

Single nucleotide polymorphisms (SNPs) are variations in a genome’s base pair in a DNA sequence, and occur in approximately 1 out of 800 base pairs. These occur when a single nucleotide is ...

1. We studied a perch Perca fluviatilis L. population that during a 9-year period switched between a phase of dominance of adult perch and a phase dominated by juvenile perch driven by cannibalism and ...