(a) Represen-tative raster plot of changes in the firing patterns induced by repetitive correlated presynaptic and postsynaptic stimulation, showing spike times during injection of a step current ...

Summary: New research uncovers how tau pathology spreads and damages synapses in progressive supranuclear palsy (PSP). Using ...

These results reveal a previously unknown action of TRPV1 channels and indicate that the postsynaptic generation of endocannabinoids can modulate synaptic strength in a cell type–specific ...

A research group led by Specially appointed professor, Dr. Tatsuo Suzuki of Shinshu University's School of Medicine developed a new purification protocol for Postsynaptic density (PSD) lattice, a ...

Postsynaptic density (PSD) is an extremely large multi-protein complex that is responsible for positioning signaling molecules that potentiate both the long-term potentiation and depression of ...

These events evoke the depolarization of the postsynaptic membrane, inducing transmission of a signal. N-methyl D-aspartate (NMDA) is one of the most common types of glutamate ionotropic receptors.

(1) A nerve impulse arrives. (2) This causes calcium ion channels to open, resulting in an influx of calcium ions in the terminal. (3) This causes synaptic vesicles to fuse with the terminal ...

In general, antidepressants that bind to these receptors do so with greater affinity for these postsynaptic receptors than neurotransmitters for these receptors (Wilcox, Gonzales, & Miller, 1998).

Decades-old assumptions about brain plasticity upended Date: June 3, 2025 Source: University of Pittsburgh Summary: Your brain doesn t just send messages through one universal route it uses ...