乳腺癌（BC）发病率和死亡率逐年上升，转移是患者预后差和死亡主因，骨转移尤为突出。Ras-proximate-1（RAP1）在 BC 等疾病中上调且影响肿瘤转移，但相关研究较少。本文综述 RAP1 在 BC 骨转移中的致病作用、相关信号通路及调节 BC 骨转移的天然化合物，为防治 BC 骨转移提供新思路。

Proximate leaders should be leading, not following, the field’s cadre of academic, nonprofit, governmental, and business experts in creating solutions to their community’s challenges. Not only should ...

“Wherever you do, find ways to get proximate to people who are suffering,” he began. The Commencement Choir, conducted by Lecturer in Music John Corrie, sings “Who Is Wise” during Commencement on May ...

Ethan Leib, Professor at Fordham Law School, argues that that New York courts mistakenly apply the tort concept of “proximate cause” to contract law and calls upon the New York Court of ...

Getting Proximate — Flipping the Mentorship Paradigm to Promote Health Equity. Published December 8, 2021. N Engl J Med 2021; 385: e89. DOI: 10.1056/NEJMpv2116137. VOL. 385 NO. 24.