In the study, the investigators used metabolomics and CRISPR-Cas9 genome editing to target and inhibit pyrimidine synthesis ...

This diagram depicts the chemical structure of pyrimidine, a six-membered aromatic ring with two nitrogen atoms at positions 1 and 3 (highlighted in blue). The remaining positions are occupied by ...

Cancer cells must have access to pyrimidine supplies to produce more cancer cells and to produce uridine nucleotides, a primary fuel source for cancer cells as they rapidly reproduce, grow ...

The purine structure consists of a pyrimidine ring (positions 1 to 6) fused to an imidazole ring (positions 7 to 9). Adenine and guanine, the two most common purines in DNA and RNA, share this core ...