This article argues that recombination has a far more important role in the evolution of plant genomes than is currently appreciated, and that genome-wide patterns of recombination might explain ...

Many aspects of meiotic recombination, such as its initiation via Spo11-generated DSBS, are highly conserved throughout evolution. We are examining the mechanisms that control the distribution of ...

Unlike its DNA repair role in somatic cells, homologous recombination has a distinct role in meiosis in ensuring proper chromosome segregation. In yeast, an early step of the meiotic program is the ...

Genetic recombination is the transmission-genetic process by which the combinations of alleles observed at different loci in two parental individuals become shuffled in offspring individuals. In ...

Scientists have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer's disease brains. The study reveals for the first time how the Alzheimer&apos ...

The homologous recombination pathway is a complex cellular process that functions to repair double-strand breaks in DNA. Homologous recombination deficiency (HRD) is a common and well-described ...

That recombination seems to happen in both healthy and diseased cells. The significance is yet to be understood. The gene sequences analyzed in this study are known as Alu and L1; these are long ...

Homologous recombination deficiency (HRD) identifies a clinically relevant subgroup of patients with pancreatic cancer (pancreatic ductal adenocarcinoma). However, clinically relevant HRD is still ...

Homologous-recombination deficiency was defined as the presence of a BRCA deleterious mutation, a score of at least 42 on the myChoice test, 9-11 or both. Test scores ...

Metastatic castration-resistant prostate cancer is a heterogeneous disease with poor outcomes. 1-6 Tumors in up to 30% of patients harbor deleterious aberrations in genes involved in repairing DNA ...