Mutations that disrupt the splicing code, or the machinery required for splicing and its regulation, have roles in a range of diseases. It is also becoming apparent that genetic variation that ...

2021年5月16日讯/生物谷BIOON/---选择性剪接（alternative splicing）是一种转录后调控机制，对转录组和蛋白质组的多样性至关重要 ...

这些研究人员发现了sf3b1基因突变如何导致癌症，这些突变发生在许多癌症类型中，包括各种白血病、骨髓增生异常综合征、黑色素瘤、乳腺癌 ...

The splicing factor SRSF1 is an oncoprotein that is upregulated in human tumors, including breast cancer tumors. New in vitro and in vivo analyses reveal SRSF1's ability to transform human mammary ...

Akari Therapeutics plc announced that it is continuing key research on its antibody-drug conjugate (ADC) payload PH1 to ...

Splicing is a process necessary for the correct synthesis of proteins and an essential step in gene expression. An impaired ...

Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, are devastating and incurable diseases.

While humans can escape the heat by seeking shade or shedding layers, plants remain rooted in place. So how do they survive ...

More than 95 percent of human genes undergo alternative splicing and >50 percent of genes use alternative polyadenylation sites. For many genes, pre-mRNA processing directs expression of functionally ...

This study entailed the integration of multiple-omics datasets to examine the dysregulation in the host splicing mechanism and alteration in protein isoforms among COVID-19 patients.

Splicing removes interrupting segments called introns from the raw, unedited RNA copy of a gene, leaving only the exons, or protein-coding regions.