Xenografted human CLL cells preferentially reside and proliferate in the SP of NSG mice. We injected 1 × 10 8 human PBMCs from CLL patients into NSG mice and obtained repeat blood counts. After 1 ...

A human malignant pleural mesothelioma was xenografted serially in athymic nude Rowett rats for 27 passages during 33 months. After the two initial passages (P), the take rate during P3-9 was 100% ...

Since microglia play a critical role in resolving amyloid pathology and it has been previously demonstrated that microglia function can be induced by TREM2 activation, TREM2 agonism has been ...

Radiofrequency ablation (RFA) is the most common curative alternative. Dbait are new molecules that inhibit DNA double-strand breaks repair. In vitro, Dbait has shown to increase cell death after ...

In September 27 Science, Melanie Snow and colleagues from Monash University, Victoria, Australia, show that fertile adult mice can be generated from xenografted murine ovaries (Science, 297:2227, ...

Relative to xenografted control mice, or to ungrafted APP-KI mice, the APP-KI mice hosting human neurons had elevated p-tau181 and p-tau231 in their plasma. This suggested that, when faced with ...