研究人员使用携带人类LILRB4转基因且具有淀粉样蛋白（A）沉积的小鼠模型，通过LILRB4靶向单抗进行干预时发现：LILRB4单抗可降低A积累并减轻A相关的行为异常；LILRB4单抗增强了小胶质细胞活性；减少干扰素诱导基因的表达，可以减轻神经炎症。

Microglia play a crucial role in neuroinflammation after ischemic brain injury. Previous data have shown that leukocyte immunoglobulin-like receptor B4 (LILRB4) was upregulated in mice after middle ...

中枢神经系统疾病领域 中枢神经系统疾病领域汇聚了4位表现不凡的“选手”：LILRB4、PCDHA9、TRPC5和ZBTB21。这些靶点在阿尔茨海默病（AD）、肌萎缩侧 ...

Previous data have shown that leukocyte immunoglobulin-like receptor B4 (LILRB4) was upregulated in mice after middle cerebral artery occlusion (MCAO), but the role it plays here is not well ...

One study explored the function of LILRB4, a member of the LILR family, in macrophages. It was found that LILRB4 can co-tether fibronectin with integrins on macrophages, suggesting a mechanism by ...