Knowing that pancreatic cancer can thrive on fat, and that eIF4E is more active during fat burning, the scientists first placed the animals on a ketogenic diet, forcing the tumors to consume fats ...

eFT508 selectively blocks eIF4E phosphorylation, a mechanism used by proteins to regulate one another that effectively works as a light switch to turn a protein “on” or “off.” In the case of eIF4E, ...

About eIF4E. Eukaryotic translation initiation factor 4E (eIF4E), the main regulatory component of cap-dependent mRNA translation, selectively promotes pro-oncogenic protein synthesis in response ...

The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well as others.

DURHAM, N.C.--(BUSINESS WIRE)--Ribometrix, a biotechnology company developing small molecule therapeutics that modulate RNA biology, presented the latest data from its eIF4E program at the ...

Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5′ ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we ...

They measured dopamine release in mice with mutation in the eIF4E gene, which is important for making new proteins. Mutations in this gene have been linked to autism in patients. These mice have ...

These phosphorylation events control the Maskin-eIF4E interaction and, as a result, translation of cyclin B1 mRNA. Cell cycle progression requires this Maskin-mediated translational regulation.

The eukaryotic translation initiation factor eIF4E is an oncogene elevated in an estimated 30% of cancers. The traditional view is that eIF4E drives proliferation and survival by increasing the ...

RESULTS: All 65 patients had elevated levels of eIF4E in the tumors. Thirty-six patients (55%) had elevated eIF4E in histologically tumor-free margins, and 20 of these patients (56%) have had ...

Ruggero's team utilized a mouse model of pancreatic cancer to test the effects of tomivosertib, a drug that inhibits phosphorylated eIF4E, in combination with a ketogenic diet. With their only food ...