New research maps Huntington’s disease progression like a symphony unraveling. The brain first overcommunicates, then loses sync, and finally falls silent, each stage driven by different biological ...

The Huntington’s disease mutation worsens over time like a dangerous snowball. By harnessing the power of the gene editing tool CRISPR, scientists may have found a way to interrupt the HD mutation and ...

This is a bit like a detective catching a villain earlier in a mystery, before they cause more havoc. The HDDMS gives doctors and researchers a sharper magnifying glass to track the disease’s subtle ...

Researchers have updated the system that classifies Huntington’s disease progression. Tracking progression in 4 stages will make clinical trial screening and data interpretation easier and faster, and ...

The HDBuzz editorial team had a virtual sit-down with HDBuzz founder, editor emeritus, Huntington’s disease (HD) researcher, and neurologist Professor Ed Wild. We laughed, we cried… actually we just ...

A recent publication discusses a non-invasive way of measuring levels of expanded HTT protein in the brain, using an imaging tool called a PET tracer. The results were variable, but there’s still a ...

As we wave goodbye to 2024, the HDBuzz team reflects on a year marked by significant progress, challenges, and hope. From breakthroughs at the lab bench, advancements in drug development, and both ...

Leora Fox trained as a Huntington’s Disease scientist, and obtained her PhD in 2016 at Columbia University, where she studied HD mouse models and how brain cells dispose of huntingtin protein. After ...

A recent study used miniature 3D brain models grown from stem cells to explore how the genetic change that causes Huntington’s disease (HD) might impact early brain development, before neurons even ...

After receiving a high dose of uniQure’s gene therapy for Huntington’s disease, a few patients experienced serious side effects, but are now recovering. HDBuzz explores what this means for the ...

For people at risk of Huntington’s disease, having a baby who might inherit HD can make decisions around planning a family extremely difficult. This article explains the options available, and how ...

Moving drugs from the lab bench to pharmacy shelves is no small task. In this article we delve into the role regulatory oversight plays in clinical trials and the approval of medicines for ...