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In kinesin–ADP 5, similar to tubulin:kinesin–ATP 11, the nucleotide is bound by interactions with P-loop subdomain residues and by the completely conserved Switch2 N-terminal residue, Asp231.
英国药理学:小檗胺和瓦巴因靶向Na+K+- atp酶与索拉非尼协同抑制肝癌 多激酶抑制剂索拉非尼是治疗晚期肝细胞癌(HCC)的一线药物。然而,肝癌患者对 ...
In general, ATP concentrations must be maintained above 1 mM, with a high ATP/ADP.Pi ratio, in order to sustain the energy needed for RNA and nucleotide biosynthesis.
Researchers aim to apply these findings to produce more complex ATP- and ADP-coupled biomolecules to investigate their role and significance in cell function. “Our ultimate goal is to elucidate their ...
When ATP or ADP were added, this further increased gripping and friction, indicating two mechanisms of motor-DNA interaction -- nucleotide-dependent and nucleotide-independent.