SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors. Blocking this interaction with inhibitors could ...

Study reveals how the JAK inhibitor lowers ACE2 expression and viral entry in individuals with a genetic risk variant linked to autoimmune diseases. Study: Tofacitinib Mitigates the Increased SARS ...

Researchers at Demokritus University of Thrace, Institute of Applied Biosciences Centre for Research and Technology Hellas, National Hellenic Research Foundation and University of Athens have ...

WebMD gives information about how ACE inhibitors work in treating heart disease.

Angiotensin-converting enzyme 2 (ACE2) is considered an important therapeutic target for controlling cardiovascular diseases and severe acute respiratory syndrome (SARS) outbreaks. Recently solved ...

Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain Inhibitors ...

Researchers identify potential ACE2 inhibitors through a virtual screening protocol.

Circulating Plasma Concentrations of Angiotensin-Converting Enzyme 2 in Men and Women with Heart Failure and Effects of Renin-Angiotensin-Aldosterone Inhibitors.

Molecular dynamics simulation assisted engineering of recombinant soluble human ACE2 N-glycosylation by site-directed mutagenesis or glycosidase treatment yields a superior SARS-CoV-2 decoy receptor.

Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells ...

Early in the Covid-19 pandemic, concern abounded that treatment with renin-angiotensin-system (RAS) inhibitors, such as angiotensin converting enzyme (ACE) inhibitors, or angiotensin receptors ...