which are involved in aldosterone synthesis[2]. This research is vital as it helps identify structural features that can enhance the selectivity of new drug candidates, potentially leading to more ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

Although there seem to be some exceptions, most heterozygotes/carriers are asymptomatic. Complete loss of function pathogenic variants of the CYP21A2 gene are associated with impaired cortisol and ...

Deregulation of the mechanisms regulating aldosterone biosynthesis results in primary aldosteronism (PA), the most common form of secondary hypertension with an estimated prevalence of about 10% in ...

Another possibility is that HDL-C stimulates synthesis of a mineralocorticoid other than aldosterone. We measured only one other plasma steroid, and lipoprotein levels did not appear to affect ...

Aldosterone adversely affects all of these processes. It produces both a vasculopathy and left ventricular dysfunction and fibrosis. Endothelial dysfunction in the coronary arteries can lead to acute ...

The analysis included 1498 sequenced urinary peptides detectable in ≥30% of patients and carboxyterminal propeptide of procollagen I (PICP) and PICP/carboxyterminal telopeptide of collagen I (CITP) as ...

Estrogen stimulates angiotensin synthesis and enhances aldosterone-mediated water and sodium retention, making it responsible for such unpleasant symptoms as bloating, breast tenderness ...

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Microsoft Program Synthesis using Examples SDK is a framework of technologies for the automatic generation of programs from input-output examples. This repo includes samples and sample data for the ...

A recent breakthrough by researchers from Shinshu University, Japan, is changing this landscape. The team has successfully achieved the first total synthesis of inaoside A, a natural compound found in ...