α-catenin, axin, APC, and Tcf family transcription factors. Recent crystal structures show how β-catenin can achieve this remarkably diverse functionality. In its cell adhesion role, β-catenin ...

mediated by the stabilization of beta-catenin within the cell, where it can function as a transcriptional co-activator with Tcf/Lef family members in the nucleus. Several lines of evidence suggest ...

Full details of the poster are as follows: Title: “A Phase 1/2 study of FOG-001, a first-in-class direct β-catenin:TCF inhibitor ... of the various APC and beta-catenin mutations that typically ...

The lead drug emerging from the biotech's Helicon platform is billed as a "first-and-only-in-class" direct TCF-blocking beta-catenin inhibitor, which FogPharma says has potential as a treatment ...