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HiFi测序揭密DNA复制时核小体如何重新填充染色质纤维
基于RASAM,研究人员发现了新复制染色质的独特组织结构,揭示了单分子层面上转录因子(TF)与核小体之间对调控DNA的竞争。 为实现RASAM,需先证明PacBio HiFi长读长测序技术可用于检测核苷酸类似物溴脱氧尿苷(BrdU)。于是,研究人员训练了一个预测模型(卷积 ...
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