Ereshefsky took 21 patients with severe schizophrenia who had been stable on Clozaril for at least 3 months and randomized them to receive either generic clozapine or Clozaril for 2 weeks.

With clozapine, other problems seem to be overshadowed by the possibility of neutropenia. These include serious conditions such as pneumonia, seizures, myocardiopathy, and constipation. Ileus is ...