This process has been demonstrated in vivo for LTB 4, but not for cysteinyl LTs (cysLTs). We examined transcellular cysLT synthesis during zymosan-induced peritonitis, using bone marrow transplants ...

Cysteinyl leukotrienes (cys-LTs) are proinflammatory mediators and regulate endothelial cell contraction, permeability, and angiogenesis via a cys-LT receptor, CysLT 2 R. In response to the challenges ...

Background: Cysteinyl leukotrienes (Cys-LTs) and isoprostanes are inflammatory metabolites derived from arachidonic acid whose levels are increased in the airways of asthmatic patients. Isoprostanes ...

Pulmonary eosinophilia developed while he was receiving treatment with montelukast, a chemically distinct cysteinyl leukotriene type 1 receptor antagonist. After discontinuation of montelukast therapy ...

Decreased production of anti-inflammatory prostanoid PGE 2 and increased activity of LTC 4 synthase, which is the rate-limiting step in cysteinyl LT synthesis, appear to play a major role in AIA ...

The cysteinyl LTs exert their biological action by binding to two types of G-protein-coupled 7-transmembrane receptors, CysLT1 and CysLT2.

Asparaginyl endopeptidases (AEPs) are cysteinyl enzymes naturally catalyzing the hydrolysis and transpeptidation reactions at Asx–Xaa bonds. These reactions go by a common acyl-enzyme thioester ...

Native mass spectrometry (MS) involves the analysis and characterization of macromolecules, predominantly intact proteins and protein complexes, whereby as much as possible the native structural ...

Hong Qian, Ph.D, professor in Molecular Hematology, a group leader for the research group Leukemia niche [1] at the Center for Hematology and Regenerative Medicine (HERM) at Karolinska Institutet.