The weakening of dystrophin, a protein linking the cell membrane to the contractile apparatus of the heart, may be a common final pathway in the contractile dysfunction in dilated cardiomyopathies.

Biophysical characterization of the dystrophin C-terminal domain: Dystrophin interacts differentially with dystrobrevin isoforms. Journal of Biological Chemistry , 2024; 300 (12): 108002 DOI: 10. ...

A new study has shed light on the complex interactions between dystrophin, a protein critical to muscle stability, and its partner protein, dystrobrevin, offering new pathways for understanding ...

Dystrophin is a large (427-kD) cytoskeletal protein. 1 The dystrophin gene has 79 exons and is too large to fit inside a recombinant adeno-associated virus (rAAV).

AURORA, Colo. (Dec. 31, 2024) – A groundbreaking study has shed light on the complex interactions between dystrophin, a protein critical to muscle stability, and its partner protein ...

DMD, a severe genetic disorder that causes muscle weakness and shortens lifespans, arises from mutations in the gene encoding dystrophin. While current treatments can extend patients’ lifespans ...

Scientists have discovered a new form of dystrophin, a protein critical to normal muscle function, and identified the genetic mechanism responsible for its production. Studies of the new protein ...

Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to ...