However, dendritic cells (DCs), which rely on a specialized endocytic machinery that confers them the unique ability to “cross”-present antigens acquired by internalization, may use distinct MHC I ...

Endocytic circuitries have emerged as complex connectivity infrastructures for numerous cellular networks required for the execution of different biological processes, with a primary role in the ...

An analogous situation probably exists for membrane mechanochemical activities. For example, the endocytic machinery has to generate sufficient force to bend the membrane bilayer and form an ...

研究者使用冷冻电子显微镜、AlphaFold24和基于分子动力学的改进的综合方法，在大多数区域展示了亚纳米分辨率的apoB100的结构。该结构由一个大的球状N端结构域和一个约61纳米长的连续两亲β片组成，该β片像带一样包裹着LDL颗粒。准对称分布在β带两侧的是9个战略性的链间插入物，它们延伸到脂质表面，通过远程相互作用的网络提供额外的结构支持。

A team led by UT Southwestern Medical Center researchers has identified a key mechanism responsible for endosomal recycling in cells, a process critical to human health. Their findings, published in ...

First, whole microorganisms can transiently exist in the extracellular space and be taken up by DCs into the endocytic pathway, where relevant antigens are loaded onto MHC class II molecules in ...

Known as endocytic recycling, this process is essential to cellular tasks such as nutrient uptake, intercellular communication, adhesion, and migration. Scientists have tied its disruption to ...

由于对超分辨显微成像技术的贡献，埃里克·白茨格 (Eric Betzig)于2014年获得了诺贝尔化学奖。在今天的Frontiers for Young Minds诺贝尔奖得主文章中，白茨格讲述了他在超分辨显微成像技术领域的开创性研究，突破了光学衍射的极限，让科学家们能够看到活细胞中单个分子的运动。

Mitochondrial DNA (mtDNA) is actively removed during spermatogenesis in a conserved process that enforces the uniparental ...

Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

Brian's research focuses intersections between circadian rhythm and cancer. He utilizes cell line and mouse models of MYC-driven lung cancer to focus on how amplified MYC and metabolic stress disrupt ...